Effects of all-trans retinoic acid on tumor recurrence and metastasis
نویسندگان
چکیده
منابع مشابه
Effects of all-trans retinoic acid on tumor recurrence and metastasis.
OBJECTIVE All-trans-retinoic acid (ATRA) promotes cell differentiation. We have studied its effect on the local recurrence and metastatic spreading of an experimental rhabdomyosarcoma in rats. DESIGN syngenic rhabdomyosarcoma cells (S4MH) were inoculated s.c. in male WAG/RijCrl rats. After 25 days tumors were excised and a 40% hepatectomy was performed for all animals. Ten days later the rats...
متن کاملAll-trans-retinoic acid: measurement
A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
متن کاملAll-trans-retinoic acid and bleeding/thrombosis.
Hematology-Oncology Department Ospedali Riuniti Largo Barozzi, 1 24128 Bergamo (Italy) Tel. 39 035 269492, Fax 39 035 266659 E-Mail [email protected] All-trans-retinoic acid (ATRA) inhibits cell growth and proliferation by inducing cyto-differentiation and/or apoptosis in several cell types. These effects have become a therapeutic objective in human cancers. In addition to these functions, ...
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background: uterine leiomyoma is the most common tumor among the female in the reproductive period. the first step to control the tumor is employing medical treatment. currently gnrh agonists are the most common drugs for medical therapy of uterine myoma. climacteric-like symptoms and osteoporosis and recurrence of the size of tumor after gnrh agonists consumption are among the most common sid...
متن کاملEffect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells
OBJECTIVE To investigate the effect of all-trans retinoic acid(ATRA) on the proliferation and differentiation of brain tumor stem cells(BTSCs) in vitro. METHODS Limiting dilution and clonogenic assay were used to isolate and screen BTSCs from the fresh specimen of human brain glioblastoma. The obtained BTSCs, which were cultured in serum-free medium, were classified into four groups in accord...
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ژورنال
عنوان ژورنال: Revista Española de Enfermedades Digestivas
سال: 2005
ISSN: 1130-0108
DOI: 10.4321/s1130-01082005000400004